By 2021, several virtualization platforms have matured to the point where simulating Win2K is trivial. However, not all are created equal. Below is the ultimate toolkit.
This is the real deal. The retro community has curated pre-built Windows 2000 Professional SP4 images that run flawlessly on modern hardware.
First, there is the legitimate preservationist side: running actual Windows 2000 ISOs through virtualization software like VirtualBox or VMware. This is clunky, technical, and prone to driver errors.