With significant compromises, yes – but only on older Macs or via virtual machines. On modern macOS (Catalina+), a true, seamless, portable CS6 experience does not exist. The 32-bit app is dead.
Given the security risks and instability of "portable" legacy software, consider these modern, one-time purchase or low-cost options: Affinity Photo photoshop cs6 portable mac work
Adobe Photoshop CS6 Portable is an unofficial, unauthorized modification of the standard Adobe Photoshop CS6 software. It is designed to run without a formal installation process. While popular for its convenience and lack of licensing requirements, the macOS version of this software faces severe compatibility issues with modern hardware and operating systems. Furthermore, its use presents significant security risks and legal liabilities. With significant compromises, yes – but only on
If portability is your main goal, use Photopea (works offline if you enable service workers) or a portable GIMP build. If you need Photoshop’s exact workflow, subscribe to CC and accept the installation. Given the security risks and instability of "portable"