Pharmacology In Drug Discovery And Development Site

Examines "what the drug does to the body," focusing on the molecular mechanisms of action, dose-response relationships, and therapeutic effects. Longdom Publishing SL The Drug Discovery & Development Pipeline

Understanding the relationship between a drug and the body is split into two critical classes: pharmacology in drug discovery and development

Before a drug can be tested in humans, it must prove it is safe enough to try. This is the domain of preclinical pharmacology. Examines "what the drug does to the body,"

Beyond general toxicity, safety pharmacology looks at vital systems. Does the drug cause ? If yes, it prolongs the QT interval in the heart, risking sudden cardiac death (Torsade de Pointes). Thousands of promising antidepressants and antihistamines have been terminated due to hERG liability. Beyond general toxicity, safety pharmacology looks at vital

A molecule might be a perfect assassin for a disease-causing protein in a petri dish, but if the human liver destroys it instantly, it is useless as a medicine. Pharmacokinetics analyzes the fate of the drug through the acronym ADME :