Steam Must Be Running To Play This — Game Resident Evil 4 Solution

This error is a Digital Rights Management (DRM) handshake failure. Essentially, the game is trying to verify your license with Steam’s background service (the Steam.exe client), but the communication is broken.

Once all overlays are disabled, restart the game. If it works, re-enable them one by one to find the culprit. This error is a Digital Rights Management (DRM)

Close Steam completely (check the system tray to ensure it's not running in the background). restart the game. If it works